[HTML][HTML] Computational modeling of the human auditory periphery: Auditory-nerve responses, evoked potentials and hearing loss

S Verhulst, A Altoe, V Vasilkov - Hearing research, 2018 - Elsevier
Abstract Models of the human auditory periphery range from very basic functional
descriptions of auditory filtering to detailed computational models of cochlear mechanics …

Unified cochlear model for low-and high-frequency mammalian hearing

A Sasmal, K Grosh - … of the National Academy of Sciences, 2019 - National Acad Sciences
The spatial variations of the intricate cytoarchitecture, fluid scalae, and mechano-electric
transduction in the mammalian cochlea have long been postulated to provide the organ with …

Enhancing the sensitivity of the envelope-following response for cochlear synaptopathy screening in humans: The role of stimulus envelope

V Vasilkov, M Garrett, M Mauermann, S Verhulst - Hearing Research, 2021 - Elsevier
Auditory de-afferentation, a permanent reduction in the number of inner-hair-cells and
auditory-nerve synapses due to cochlear damage or synaptopathy, can reliably be …

A convolutional neural-network framework for modelling auditory sensory cells and synapses

F Drakopoulos, D Baby, S Verhulst - Communications Biology, 2021 - nature.com
In classical computational neuroscience, analytical model descriptions are derived from
neuronal recordings to mimic the underlying biological system. These neuronal models are …

Predicting synapse counts in living humans by combining computational models with auditory physiology

BN Buran, GP McMillan, S Keshishzadeh… - The Journal of the …, 2022 - pubs.aip.org
Aging, noise exposure, and ototoxic medications lead to cochlear synapse loss in animal
models. As cochlear function is highly conserved across mammalian species, synaptopathy …

Phase locking of auditory nerve fibers: the role of lowpass filtering by hair cells

AJ Peterson, P Heil - Journal of Neuroscience, 2020 - Soc Neuroscience
Phase locking of auditory-nerve-fiber (ANF) responses to the temporal fine structure of
acoustic stimuli, a hallmark of the auditory system's temporal precision, is important for many …

Optimized tuning of auditory inner hair cells to encode complex sound through synergistic activity of six independent K+ current entities

M Dierich, A Altoe, J Koppelmann, S Evers… - Cell Reports, 2020 - cell.com
Auditory inner hair cells (IHCs) convert sound vibrations into receptor potentials that drive
synaptic transmission. For the precise encoding of sound qualities, receptor potentials are …

[HTML][HTML] Characterization of the decline in auditory nerve phase locking at high frequencies

J Klug, J Encke, M Dietz - JASA express letters, 2023 - pubs.aip.org
The frequency dependence of phase locking in the auditory nerve influences various
auditory coding mechanisms. The decline of phase locking with increasing frequency is …

Towards a differential diagnosis of cochlear synaptopathy and outer-hair-cell deficits in mixed sensorineural hearing loss pathologies

V Vasilkov, S Verhulst - medRxiv, 2019 - medrxiv.org
Damage to the auditory periphery is more widespread than predicted by the gold-standard
clinical audiogram. Noise exposure, ototoxicity and aging can destroy cochlear inner-hair …

Phase locking of auditory-nerve fibers reveals stereotyped distortions and an exponential transfer function with a level-dependent slope

AJ Peterson, P Heil - Journal of Neuroscience, 2019 - Soc Neuroscience
Phase locking of auditory-nerve-fiber (ANF) responses to the fine structure of acoustic stimuli
is a hallmark of the auditory system's temporal precision and is important for many aspects of …