Skeletal muscle: A review of molecular structure and function, in health and disease

K Mukund, S Subramaniam - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Skeletal muscle extracellular matrix–what do we know about its composition, regulation, and physiological roles? A narrative review

R Csapo, M Gumpenberger, B Wessner - Frontiers in physiology, 2020 - frontiersin.org
Skeletal muscle represents the largest body-composition component in humans. In addition
to its primary function in the maintenance of upright posture and the production of …

Exercise is the real polypill

C Fiuza-Luces, N Garatachea, NA Berger… - Physiology, 2013 - journals.physiology.org
The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

Skeletal muscle fibrosis: an overview

MAA Mahdy - Cell and tissue research, 2019 - Springer
Extracellular matrix (ECM) is an essential component of skeletal muscle. It provides a
framework structure that holds myofibers and blood capillaries and nerves supplying the …

Muscle and bone, two interconnected tissues

C Tagliaferri, Y Wittrant, MJ Davicco, S Walrand… - Ageing research …, 2015 - Elsevier
As bones are levers for skeletal muscle to exert forces, both are complementary and
essential for locomotion and individual autonomy. In the past decades, the idea of a bone …

Exercise-induced myokines and their effect on prostate cancer

JS Kim, DA Galvão, RU Newton, E Gray… - Nature Reviews …, 2021 - nature.com
Exercise is recognized by clinicians in the field of clinical oncology for its potential role in
reducing the risk of certain cancers and in reducing the risk of disease recurrence and …

Aberrant repair and fibrosis development in skeletal muscle

CJ Mann, E Perdiguero, Y Kharraz, S Aguilar… - Skeletal muscle, 2011 - Springer
The repair process of damaged tissue involves the coordinated activities of several cell
types in response to local and systemic signals. Following acute tissue injury, infiltrating …

Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication

Y Qin, Y Peng, W Zhao, J Pan… - Journal of Biological …, 2017 - ASBMB
Muscle and bone are closely associated in both anatomy and function, but the mechanisms
that coordinate their synergistic action remain poorly defined. Myostatin, a myokine secreted …

Plasminogen activator inhibitor‐1 (PAI‐1): a key factor linking fibrinolysis and age‐related subclinical and clinical conditions

M Cesari, M Pahor, RA Incalzi - Cardiovascular therapeutics, 2010 - Wiley Online Library
Introduction: The close relationship existing between aging and thrombosis has growingly
been studied in this last decade. The age‐related development of a prothrombotic …

Cellular mechanisms of tissue fibrosis. 4. Structural and functional consequences of skeletal muscle fibrosis

RL Lieber, SR Ward - American Journal of Physiology-Cell …, 2013 - journals.physiology.org
Skeletal muscle fibrosis can be a devastating clinical problem that arises from many causes,
including primary skeletal muscle tissue diseases, as seen in the muscular dystrophies, or it …