Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …

Ethanol-induced oxidative stress seems to play a major role in mechanisms by which
ethanol causes liver injury. Many pathways have been suggested to contribute to the ability …

Background & Aims: Chronic alcohol drinking accelerates liver fibrosis in patients with viral
hepatitis that cannot be fully explained by ethanol-enhanced liver damage. Here, we …

Excessive alcohol consumption is a global healthcare problem with enormous social,
economic, and clinical consequences. While chronic, heavy alcohol consumption causes …

Autophagy is an evolutionarily conserved pathway for degradation of cytoplasmic proteins
and organelles via lysosome. Proteins coded by the autophagy-related genes (Atgs) are the …

This paper is based upon the “Charles Lieber Satellite Symposia” organized by Manuela G.
Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014 …

Hepatocellular carcinoma (HCC) is one of the most common cancers with a dismal outcome.
The complicated molecular pathogenesis of HCC caused by tumor heterogeneity makes it …

Chronic lung allograft dysfunction (CLAD) is the major barrier to long-term survival following
lung transplantation, and new mechanistic biomarkers are needed. Lymphocytic bronchitis …

Background Alcohol consumption exacerbates the pathogenesis of hepatitis C virus (HCV)
infection and worsens disease outcomes. The exact reasons are not clear yet, but they might …

During the last two decades nitric oxide (NO) produced by inducible NO synthase (iNOS or
NOS2) has been characterized as immunoregulatory and antimicrobial principle displaying …