Major depressive disorder (MDD) is a severe psychiatric condition that significantly impacts
the overall quality of life. Although MDD can occur across all age groups, it is notably …

Micro-and nano-plastics (MNPs) are ubiquitously distributed in the environment, infiltrate
organisms through multiple pathways, and accumulate, thus posing potential threats to …

The beneficial effect of a beta-lactam antibiotic, Ceftriaxone (CEF), to improve depressive-
like symptoms has been documented previously, attributed to its modulation of glutamate …

Abstract Sterile Alpha and TIR Motif Containing 1 (SARM1) are proteins implicated in
various neurological processes; however, their role in depression remains unexplored. This …

Major depressive disorder (MDD) is a debilitating illness with a high global burden. While
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, offers rapid-acting …

Sevoflurane is an inhalational anesthetic widely used in clinical settings. Accumulating
evidence has shown that sevoflurane exposure may impair cognitive function, potentially …

Background BMAL1, a key regulator of circadian rhythms, plays a multifaceted role in brain
function. However, the complex interplay between BMAL1, memory, neuroinflammation, and …

The L-type Ca2+ channel (LTCC, also known as Cav1, 2) is involved in the regulation of key
neuronal functions, such as dendritic information integration, cell survival, and neuronal …

In patients with Alzheimer's disease, gamma-glutamyl transferase 5 (GGT5) expression has
been observed to be downregulated in cerebrovascular endothelial cells. However, the …

Aim To study the role of the P2X4 receptor (P2X4R) in regulating hippocampal synaptic
impairment in lipopolysaccharide (LPS)-induced depression. Methods A rat model of …