Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity

MN Meriggioli, DB Sanders - The Lancet Neurology, 2009 - thelancet.com
Acquired myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction
in which patients experience fluctuating skeletal muscle weakness that often affects selected …

The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes

A Marx, F Pfister, B Schalke, G Saruhan-Direskeneli… - Autoimmunity …, 2013 - Elsevier
The thymus plays distinct roles in the pathogenesis of the different Myasthenia gravis (MG)
subtypes. Inflammatory, neoplastic and age-related alterations of the thymus are of pivotal …

Roles of cytokines and T cells in the pathogenesis of myasthenia gravis

A Uzawa, S Kuwabara, S Suzuki, T Imai… - Clinical & …, 2021 - academic.oup.com
Myasthenia gravis (MG) is characterized by muscle weakness and fatigue caused by the
presence of autoantibodies against the acetylcholine receptor (AChR) or the muscle-specific …

Muscle autoantibodies in myasthenia gravis: beyond diagnosis?

MN Meriggioli, DB Sanders - Expert review of clinical immunology, 2012 - Taylor & Francis
Myasthenia gravis is an autoimmune disorder of the neuromuscular junction. A number of
molecules, including ion channels and other proteins at the neuromuscular junction, may be …

Thymic malignancies: from clinical management to targeted therapies

RJ Kelly, I Petrini, A Rajan, Y Wang… - Journal of clinical …, 2011 - ascopubs.org
Purpose A key challenge in the treatment of thymoma and thymic carcinoma (TC) is in
improving our understanding of the molecular biology of these relatively rare tumors. In …

Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia

PD Burbelo, SK Browne, EP Sampaio… - Blood, The Journal …, 2010 - ashpublications.org
Patients with thymic malignancy have high rates of autoimmunity leading to a variety of
autoimmune diseases, most commonly myasthenia gravis caused by anti-acetylcholine …

Anticytokine autoantibody–associated immunodeficiency

SK Browne - Annual review of immunology, 2014 - annualreviews.org
Anticytokine autoantibodies are an emerging mechanism of disease in previously healthy
adults. Patients with these syndromes demonstrate a unique infectious phenotype …

Good syndrome: an adult-onset immunodeficiency remarkable for its high incidence of invasive infections and autoimmune complications

M Malphettes, L Gérard, L Galicier… - Clinical Infectious …, 2015 - academic.oup.com
Background. Good syndrome (GS) is a rare condition in which thymoma is associated with
hypogammaglobulinemia. It is characterized by increased susceptibility to bacterial, viral …

Thymoma related myasthenia gravis in humans and potential animal models

A Marx, S Porubsky, D Belharazem… - Experimental …, 2015 - Elsevier
Thymoma-associated Myasthenia gravis (TAMG) is one of the anti-acetylcholine receptor
MG (AChR-MG) subtypes. The clinico-pathological features of TAMG and its pathogenesis …

Etiology of myasthenia gravis: innate immunity signature in pathological thymus

P Cavalcante, P Cufi, R Mantegazza, S Berrih-Aknin… - Autoimmunity …, 2013 - Elsevier
Myasthenia gravis (MG) is an autoimmune disease affecting the neuromuscular junction
(NMJ), whose clinical hallmark is muscle weakness and early fatigability. The main target of …