Abstract The mitochondrial Permeability Transition Pore (PTP) can be defined as a Ca 2+
activated mega-channel involved in mitochondrial damage and cell death, making its …

Mitochondrion, known as the “powerhouse” of the cell, regulates ion homeostasis, redox
state, cell proliferation and differentiation, and lipid synthesis. The inner mitochondrial …

Calcium (Ca 2+) is a key regulator in diverse intracellular signaling pathways and has long
been implicated in metabolic control and mitochondrial function. Mitochondria can actively …

Mitochondrial Ca 2+ overload is proposed to regulate cell death via opening of the
mitochondrial permeability transition pore. It is hypothesized that inhibition of the …

Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major
contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is …

Abstract Mitochondrial Ca 2+(mitCa 2+) uptake controls both intraorganellar and cytosolic
functions. Within the organelle,[Ca 2+] increases regulate the activity of tricarboxylic acid …

Astrocytes are a heterogenous population of macroglial cells spread throughout the central
nervous system with diverse functions, expression signatures, and intricate morphologies …

While mitochondria oxidative phosphorylation is broadly regulated, the impact of
mitochondrial Ca2+ on substrate flux under both physiological and pathological conditions …

The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+
extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …

Increased malignancy and poor treatability associated with solid tumour cancers have
commonly been attributed to mitochondrial calcium (Ca2+) dysregulation. The mitochondrial …