The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

The bidirectional transport between the Golgi complex and the endocytic pathway has to be
finely regulated in order to ensure the proper delivery of newly synthetized lysosomal …

DNA is a versatile scaffold for molecular sensing in living cells, and various cellular
applications of DNA nanodevices have been demonstrated. However, the simultaneous use …

Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many
cellular processes including signaling, immunity, neuroprotection, and virus infection. The …

ABSTRACT Human papillomavirus 16 (HPV16) enters its host cells by a process that most
closely resembles macropinocytosis. Uncoating occurs during passage through the …

VARP is a Rab32/38 effector that also binds to the endosomal/lysosomal R-SNARE VAMP7.
VARP binding regulates VAMP7 participation in SNARE complex formation and can …

Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of
protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo …

Endosomal entrapment is a severely limiting bottleneck in the delivery of biologics into cells.
The compound dfTAT was recently found to circumvent this problem by mediating …

Intracellular transport of recombinant adeno-associated virus (AAV) is still incompletely
understood. In particular, the trafficking steps preceding the release of incoming AAV …

Conspectus DNA nanodevices are nanoscale assemblies, formed from a collection of
synthetic DNA strands, that may perform artificial functions. The pioneering developments of …