The retromer complex–endosomal protein recycling and beyond

MNJ Seaman - Journal of cell science, 2012 - journals.biologists.com
The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

Bidirectional traffic between the Golgi and the endosomes–machineries and regulation

C Progida, O Bakke - Journal of cell science, 2016 - journals.biologists.com
The bidirectional transport between the Golgi complex and the endocytic pathway has to be
finely regulated in order to ensure the proper delivery of newly synthetized lysosomal …

Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell

S Modi, C Nizak, S Surana, S Halder… - Nature …, 2013 - nature.com
DNA is a versatile scaffold for molecular sensing in living cells, and various cellular
applications of DNA nanodevices have been demonstrated. However, the simultaneous use …

Architecture and mechanism of metazoan retromer: SNX3 tubular coat assembly

N Leneva, O Kovtun, DR Morado, JAG Briggs… - Science …, 2021 - science.org
Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many
cellular processes including signaling, immunity, neuroprotection, and virus infection. The …

Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection

PM Day, CD Thompson, RM Schowalter… - Journal of …, 2013 - Am Soc Microbiol
ABSTRACT Human papillomavirus 16 (HPV16) enters its host cells by a process that most
closely resembles macropinocytosis. Uncoating occurs during passage through the …

VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface

GG Hesketh, I Pérez-Dorado, LP Jackson, L Wartosch… - Developmental cell, 2014 - cell.com
VARP is a Rab32/38 effector that also binds to the endosomal/lysosomal R-SNARE VAMP7.
VARP binding regulates VAMP7 participation in SNARE complex formation and can …

Protein sorting from endosomes to the TGN

DP Buser, A Spang - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of
protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo …

The late endosome and its lipid BMP act as gateways for efficient cytosolic access of the delivery agent dfTAT and its macromolecular cargos

A Erazo-Oliveras, K Najjar, D Truong, TY Wang… - Cell chemical …, 2016 - cell.com
Endosomal entrapment is a severely limiting bottleneck in the delivery of biologics into cells.
The compound dfTAT was recently found to circumvent this problem by mediating …

Syntaxin 5-Dependent Retrograde Transport to the trans-Golgi Network Is Required for Adeno-Associated Virus Transduction

ME Nonnenmacher, JC Cintrat, D Gillet… - Journal of virology, 2015 - Am Soc Microbiol
Intracellular transport of recombinant adeno-associated virus (AAV) is still incompletely
understood. In particular, the trafficking steps preceding the release of incoming AAV …

Quantitative Chemical Imaging of Organelles

JA Tinker, P Anees, Y Krishnan - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus DNA nanodevices are nanoscale assemblies, formed from a collection of
synthetic DNA strands, that may perform artificial functions. The pioneering developments of …