Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …

Nearly 130 years after the first insights into the existence of mitochondria, new
rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell …

T cell activation is associated with a profound and rapid metabolic response to meet
increased energy demands for cell division, differentiation and development of effector …

T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and
to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP …

Abstract The PI3K/AKT signaling pathway is an essential node in mammalian cells that
controls cell growth, migration, proliferation, and metabolism. During the last decade, a …

Human NK cells can be classified into phenotypically and functionally distinct subsets based
on levels of CD56 receptor. CD56 dim cells are generally considered more cytotoxic …

Solute carrier (SLC) transporters meditate many essential physiological functions, including
nutrient uptake, ion influx/efflux, and waste disposal. In its protective role against tumors and …

T cell activation potently stimulates cellular metabolism to support the elevated energetic
and biosynthetic demands of growth, proliferation, and effector function. We show that …

T cells undergo metabolic reprogramming and multiple biological processes to satisfy their
energetic and biosynthetic demands throughout their lifespan. Several of these metabolic …

Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias and
lymphomas (T-ALL), making this receptor a promising target for drugs such as γ-secretase …