The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …

Abstract RNA polymerase II (Pol II)-mediated transcription in eukaryotic cells starts with
assembly of preinitiation complex (PIC) on core promoter, a DNA sequence of∼ 100 base …

Nucleotide excision repair removes DNA lesions caused by ultraviolet light, cisplatin-like
compounds and bulky adducts. After initial recognition by XPC in global genome repair or a …

Transcription initiation is a complex process, and its mechanism is incompletely understood.
We determined the structures of de novo transcribing complexes TC2 to TC17 with RNA …

Most eukaryotic promoter regions are divergently transcribed. As the RNA polymerase II pre-
initiation complex (PIC) is intrinsically asymmetric and responsible for transcription in a …

The transition from transcription initiation to elongation is highly regulated in human cells but
remains incompletely understood at the structural level. In particular, it is unclear how …

The herpes virus genome bears more than 80 strong transcriptional promoters. Upon entry
into the host cell nucleus, these genes are transcribed in an orderly manner, producing five …

基因转录作为中心法则的关键环节, 将遗传信息由DNA 传递至RNA, 从而指导蛋白质的合成,
是生物体最重要的生命活动之一. 转录起始过程发生在几万种不同基因的高度多样化的启动子区 …

TFIIH is an essential transcription initiation factor for RNA polymerase II (RNApII). This multi-
subunit complex comprises two modules that are physically linked by the subunit Tfb3 …

As the key step of the genetic central dogma, transcription generates RNA using DNA as
template to control differential gene expression. The transcription initiation occurs in highly …