A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence

D Balasubramanian, L Schneper, H Kumari… - Nucleic acids …, 2013 - academic.oup.com
Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …

Matrix exopolysaccharides; the sticky side of biofilm formation

E Maunders, M Welch - FEMS microbiology letters, 2017 - academic.oup.com
Abstract The Gram-negative pathogen Pseudomonas aeruginosa is found ubiquitously
within the environment and is recognised as an opportunistic human pathogen that …

[HTML][HTML] Pseudomonas Flagella: Generalities and Specificities

M Bouteiller, C Dupont, Y Bourigault, X Latour… - International journal of …, 2021 - mdpi.com
Flagella-driven motility is an important trait for bacterial colonization and virulence. Flagella
rotate and propel bacteria in liquid or semi-liquid media to ensure such bacterial fitness …

[HTML][HTML] Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections

H Chung, C Merakou, MM Schaefers, KB Flett… - Nature …, 2022 - nature.com
Acute bacterial infections are often treated empirically, with the choice of antibiotic therapy
updated during treatment. The effects of such rapid antibiotic switching on the evolution of …

Genetics and regulation of bacterial alginate production

ID Hay, Y Wang, MF Moradali… - Environmental …, 2014 - Wiley Online Library
A vast range of extracellular polysaccharides are produced by bacteria in order to adapt to
and thrive in diverse environmental niches. Many of these polymers have attracted great …

[HTML][HTML] An atlas of bacterial two-component systems reveals function and plasticity in signal transduction

Y Xie, J Li, Y Ding, X Shao, Y Sun, F Xie, S Liu, S Tang… - Cell reports, 2022 - cell.com
Two-component systems (TCSs) consist of the biggest group of signal transduction
pathways in biology. Although TCSs play key roles in sensing signals to sustain survival and …

[HTML][HTML] Mechanisms regulating the CRISPR-Cas systems

M Zakrzewska, M Burmistrz - Frontiers in Microbiology, 2023 - frontiersin.org
The CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR
associated proteins) is a prokaryotic system that enables sequence specific recognition and …

Generation of a highly attenuated strain of Pseudomonas aeruginosa for commercial production of alginate

ME Valentine, BD Kirby, TR Withers… - Microbial …, 2020 - Wiley Online Library
Alginate is an important polysaccharide that is commonly used as a gelling agent in foods,
cosmetics and healthcare products. Currently, all alginate used commercially is extracted …

Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies

DJ Hassett, TR Korfhagen, RT Irvin… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: CF airway mucus can be infected by opportunistic microorganisms,
notably Pseudomonas aeruginosa. Once organisms are established as biofilms, even the …

Proteolytic regulation of alginate overproduction in Pseudomonas aeruginosa

FH Damron, JB Goldberg - Molecular microbiology, 2012 - Wiley Online Library
Pseudomonas aeruginosa, a Gram‐negative bacterium, is a significant opportunistic
pathogen associated with skin and soft tissue infections, nosocomial pneumonia and sepsis …