Oxidation of drugs during drug product development: problems and solutions

A Gabrič, Ž Hodnik, S Pajk - Pharmaceutics, 2022 - mdpi.com
Oxidation is the second most common degradation pathway for pharmaceuticals, after
hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex …

Flow reactors integrated with in-line monitoring using benchtop NMR spectroscopy

P Giraudeau, FX Felpin - Reaction Chemistry & Engineering, 2018 - pubs.rsc.org
The monitoring of chemical reactions on the fly conducted in flow through the use of
benchtop NMR spectroscopy is an emerging field of research allowing tremendous …

Catalytic activity of Schiff-base transition metal complexes supported on crosslinked polyacrylamides for hydrogen peroxide decomposition

B Tamami, S Ghasemi - Journal of Organometallic Chemistry, 2015 - Elsevier
A number of polymeric Schiff base-metal complexes based on crosslinked polyacrylamide
resins were synthesized and characterized. The catalytic activity of the polymeric metal …

NMR characterization of H2O2 hydrogen exchange

T Kakeshpour, A Bax - Journal of Magnetic Resonance, 2021 - Elsevier
Quantification of H 2 O 2 concentration in aqueous solutions is of interest in many fields. It
usually is based on indirect methods that rely on oxidation reactions that turn on/off …

Novel 1H low field nuclear magnetic resonance applications for the field of biodiesel

P Berman, A Leshem, O Etziony, O Levi… - Biotechnology for …, 2013 - Springer
Background Biodiesel production has increased dramatically over the last decade, raising
the need for new rapid and non-destructive analytical tools and technologies. 1 H Low Field …

Detection and quantification of hydrogen peroxide in aqueous solutions using chemical exchange saturation transfer

D Ryoo, X Xu, Y Li, JA Tang, J Zhang… - Analytical …, 2017 - ACS Publications
The development of new analytical methods to accurately quantify hydrogen peroxide is of
great interest. In the current study, we developed a new magnetic resonance (MR) method …

Imaging short‐lived reactive oxygen species (ROS) with endogenous contrast MRI

RW Tain, AM Scotti, W Li, XJ Zhou… - Journal of Magnetic …, 2018 - Wiley Online Library
Purpose To characterize the relaxation properties of reactive oxygen species (ROS) for the
development of endogenous ROS contrast magnetic resonance imaging (MRI). Materials …

Rapid 1 H NMR determination of hydrogen peroxide in cosmetic products and chemical reagents

YB Monakhova, BWK Diehl - Analytical Methods, 2016 - pubs.rsc.org
A methodology utilizing 1H NMR spectroscopy has been developed to measure the
concentration of hydrogen peroxide in hair sprays, nail treatments, hydrogen peroxide …

Earth's field NMR relaxation of pre-polarised water protons for real-time detection of free-radical formation

A Topor, MA Voda, PR Vasos - Chemical Communications, 2023 - pubs.rsc.org
Real-time imaging of free-radical formation is important in physical chemistry, biochemistry,
and radiobiology, especially for the study of radiation dose-rate effects. Herein, we show for …

Magnetic resonance imaging methods in heterogeneous catalysis

IV Koptyug - 2014 - books.rsc.org
Applications of spatially resolved magnetic resonance in heterogeneous catalysis and
related fields are considered. The chapter starts with a simple description of the basic …