The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

Background TNBC is the most aggressive breast cancer with higher recurrence and
mortality rate than other types of breast cancer. There is an urgent need for identification of …

Terpenoids are the largest class of natural products, most of which are derived from plants.
Amongst their numerous biological properties, their anti-tumor effects are of interest for they …

The generation of reactive oxygen species (ROS) and an altered redox status are common
biochemical aspects in cancer cells. ROS can react with the polyunsaturated fatty acids of …

Mitochondria are the cells' powerhouse, but also their suicidal weapon store. Dozens of
lethal signal transduction pathways converge on mitochondria to cause the permeabilization …

Reactive oxygen species (ROS) play an important role in determining the fate of normal
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …

Despite remarkable progress in the discovery and development of novel cancer
therapeutics, cancer remains the second leading cause of death in the world. For many …

Review covering up to 07/2019 (−)-Parthenolide is a germacrane sesquiterpene lactone,
available in ample amounts from the traditional medical plant feverfew (Tanacetum …

Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional
medicine against inflammation and cancer. This review focuses on the chemical and …