Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …

Concise review: multifaceted characterization of human mesenchymal stem cells for use in regenerative medicine

RM Samsonraj, M Raghunath… - Stem cells …, 2017 - academic.oup.com
Mesenchymal stem cells (MSC) hold great potential for regenerative medicine because of
their ability for self-renewal and differentiation into tissue-specific cells such as osteoblasts …

Intravascular mesenchymal stromal/stem cell therapy product diversification: time for new clinical guidelines

G Moll, JA Ankrum, J Kamhieh-Milz, K Bieback… - Trends in molecular …, 2019 - cell.com
Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …

Insights into the secretome of mesenchymal stem cells and its potential applications

S Eleuteri, A Fierabracci - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

M Madrigal, KS Rao, NH Riordan - Journal of translational medicine, 2014 - Springer
The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the
early paradigm of cell replacement and differentiation as a therapeutic mechanism of action …

[HTML][HTML] Mesenchymal stem cell homing: the devil is in the details

JM Karp, GSL Teo - Cell stem cell, 2009 - cell.com
The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to
promote regeneration of damaged tissue, to treat inflammation, and to promote …

Mesenchymal stromal cells: current understanding and clinical status

HK Salem, C Thiemermann - Stem cells, 2010 - academic.oup.com
Multipotent mesenchymal stromal cells (MSCs) represent a rare heterogeneous subset of
pluripotent stromal cells that can be isolated from many different adult tissues that exhibit the …

Stem cell-derived exosomes: a new strategy of neurodegenerative disease treatment

N Fayazi, M Sheykhhasan, S Soleimani Asl… - Molecular …, 2021 - Springer
Short-term symptomatic treatment and dose-dependent side effects of pharmacological
treatment for neurodegenerative diseases have forced the medical community to seek an …

Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis

NH Riordan, I Morales, G Fernández, N Allen… - Journal of translational …, 2018 - Springer
Background Multiple sclerosis (MS) is a progressively debilitating neurological condition in
which the immune system abnormally erodes the myelin sheath insulating the nerves …

Adult stem cells in the endometrium

CE Gargett, H Masuda - Molecular human reproduction, 2010 - academic.oup.com
Rare cells with adult stem cell activity were recently discovered in human endometrium.
Endometrial stem/progenitor cell candidates include epithelial, mesenchymal and …