The critical role of alpha-synuclein in Parkinson's disease represents a pivotal discovery.
Some progress has been made over recent years in identifying disease-modifying therapies …

Zinc is a crucial trace element in the human body, playing a role in various physiological
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …

Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer's disease
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in
over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) …

While Parkinson's disease remains clinically defined by cardinal motor symptoms resulting
from nigrostriatal degeneration, it is now appreciated that the disease commonly consists of …

Parkinson's disease (PD) is characterized by the pathologic aggregation and prion-like
propagation of α-synuclein (α-syn). Emerging evidence shows that fungal infections …

Background The accumulation and aggregation of α‐synuclein (α‐Syn) are characteristic of
Parkinson's disease (PD). Epidemiological evidence indicates that hyperlipidemia is …

Hearing loss is associated with an increased risk of Alzheimer disease (AD). However, the
mechanisms of hearing loss promoting the onset of AD are poorly understood. Here we …

The Lewy bodies and Lewy neurites are key pathological hallmarks of Parkinson's disease
(PD). Single-point mutations associated with familial PD cause α-synuclein (α-Syn) …

Oxidative stress (OS) is regarded as the dominant theory for aging. While compelling
correlative data have been generated to support the OS theory, a direct cause-and-effect …