Chromone as a privileged scaffold in drug discovery: recent advances: miniperspective
The use of privileged structures in drug discovery has proven to be an effective strategy,
allowing the generation of innovative hits/leads and successful optimization processes …
allowing the generation of innovative hits/leads and successful optimization processes …
Synthesis of biologically active molecules through multicomponent reactions
Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …
significant role that multicomponent reactions (MCRs) have played as a very important tool …
Site-selective acceptorless dehydrogenation of aliphatics enabled by organophotoredox/cobalt dual catalysis
MJ Zhou, L Zhang, G Liu, C Xu… - Journal of the American …, 2021 - ACS Publications
The value of catalytic dehydrogenation of aliphatics (CDA) in organic synthesis has
remained largely underexplored. Known homogeneous CDA systems often require the use …
remained largely underexplored. Known homogeneous CDA systems often require the use …
Organofluorine chemistry: Promising growth areas and challenges
LV Politanskaya, GA Selivanova… - Russian Chemical …, 2019 - iopscience.iop.org
Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …
area of organic chemistry. Fluorine present in a molecule largely determines its specific …
Apigenin as neuroprotective agent: Of mice and men
Neurodegenerative disorders (NDDs) such as Alzheimer's and Parkinson's diseases are the
most common age-related pathologies that affect millions of people all over the world. To …
most common age-related pathologies that affect millions of people all over the world. To …
Synthesis, biological evaluation and molecular modelling of 3-Formyl-6-isopropylchromone derived thiosemicarbazones as α-glucosidase inhibitors
Abstract Type-2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders in
the world and over the past three decades its incidence has increased drastically. α …
the world and over the past three decades its incidence has increased drastically. α …
Chromones: Privileged scaffold in anticancer drug discovery
VM Patil, N Masand, S Verma… - Chemical Biology & …, 2021 - Wiley Online Library
In the design and discovery of anticancer drugs, various natural heterocyclic scaffolds have
attracted considerable interest as privileged structures. For rational drug design, some of the …
attracted considerable interest as privileged structures. For rational drug design, some of the …
Synthesis of newer 1, 2, 3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities
The present study was carried out in an attempt to synthesize a new class of antimicrobial
and antiplasmodial agents by copper catalyzed click chemistry to afford 25 compounds 10 …
and antiplasmodial agents by copper catalyzed click chemistry to afford 25 compounds 10 …
Visible-light-induced metal-free coupling of C (sp 3)–H sources with heteroarenes
Development of an efficient, mild, economically viable, and green method for the
construction of a Csp2–Csp3 bond via coupling between a saturated hydrocarbon [(Csp3) …
construction of a Csp2–Csp3 bond via coupling between a saturated hydrocarbon [(Csp3) …
Recent advances of chroman-4-one derivatives: synthetic approaches and bioactivities
S Emami, Z Ghanbarimasir - European Journal of Medicinal Chemistry, 2015 - Elsevier
Chroman-4-one scaffold is a privileged structure in heterocyclic chemistry and drug
discovery. Also, chroman-4-ones are important intermediates and interesting building blocks …
discovery. Also, chroman-4-ones are important intermediates and interesting building blocks …