Because nonopioid analgesics are much sought after, we computationally docked more
than 301 million virtual molecules against a validated pain target, the α2A-adrenergic …

The β-adrenergic receptors (βARs) include three subtypes, β 1, β 2 and β 3. These receptors
are widely expressed and regulate numerous physiological processes including …

Introduction Strong scientific evidence and large experience support the use of β2-agonists
for the symptomatic alleviation of COPD. Therefore, there is considerable effort in …

A key question in receptor signaling is how specificity is realized, particularly when different
receptors trigger the same biochemical pathway (s). A notable case is the two β‐adrenergic …

G protein-coupled receptors (GPCRs) within the same subfamily often share high homology
in their orthosteric pocket and therefore pose challenges to drug development. The amino …

The α2A adrenergic receptor (α2AAR) is a G protein (heterotrimeric guanine nucleotide–
binding protein)–coupled receptor that mediates important physiological functions in …

The β 2 adrenergic receptor (β2AR), one of important members of the G protein coupled
receptors (GPCRs), has been suggested as an important target for cardiac and asthma …

Class AG protein‐coupled receptors (GPCRs) continue to garner interest for their essential
roles in cell signalling and their importance as drug targets. Although numerous drugs in the …

The residue located at 15 positions before the most conserved residue in TM7 (7.35 of
Ballesteros–Weinstein number) plays important roles in ligand binding and the receptor …

One of the greatest threats to human and animal health is posed by infections caused by
drug-resistant bacterial strains. Therefore, newly synthesised substances are tested for their …