Plants solely rely on innate immunity of each individual cell to deal with a diversity of
microbes in the environment. Extracellular recognition of microbe‐and host damage …

In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular …

In both plants and animals, defense against pathogens relies on a complex surveillance
system for signs of danger. Danger signals may originate from the infectious agent or from …

Blood vessels support tumours by providing nutrients and oxygen, while also acting as
conduits for the dissemination of cancer. Here we use mouse models of breast and lung …

Multicellular organisms suffer injury and serve as hosts for microorganisms. Therefore, they
require mechanisms to detect injury and to distinguish the self from the non-self and the …

Abstract Purpose of Review Allergen is an umbrella term for irritants of diverse origin. Along
with other offenders such as pathogens, mutagens, xenobiotics, and pollutants, allergens …

Altered inflammation in the early stage has long been assumed to affect subsequent steps of
the repair process that could influence proper wound healing and remodeling. However, the …

Abstract Interleukin-1 (IL-1) has long been known to be a key mediator of immunity and
inflammation. Its dysregulation has been implicated in recent years in tumorigenesis and …

Glioblastoma multiforme (GBM) is a highly aggressive neoplasia, prognosis remains dismal,
and current therapy is mostly palliative. There are no known risk factors associated with …

Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different
types of tumors, leading to improvement in survival, even in patients with advanced cancers …