Tremendous progress has been made since Neuron published our Primer on genetic
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …

Many psychiatric disorders, despite their specific characteristics, share deficits in the
cognitive domain including executive functions, emotional control and memory. However …

Summary Arc/Arg3. 1 is required for synaptic plasticity and cognition, and mutations in this
gene are linked to autism and schizophrenia. Arc bears a domain resembling retroviral …

Many attempts have been made to localize the physical trace of a memory, or engram, in the
brain. However, until recently, engrams have remained largely elusive. In this Review, we …

Exercise can improve cognitive function and has been linked to the increased expression of
brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms …

Single-cell sequencing methods have emerged as powerful tools for identification of
heterogeneous cell types within defined brain regions. Application of single-cell techniques …

In the brain, neuronal gene expression is dynamically changed in response to neuronal
activity. In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos …

INTRODUCTION RNA sequencing and in situ hybridization have revealed the presence of
an unexpectedly high number of RNA species in neuronal dendrites and axons, and many …

Memory traces are believed to be ensembles of cells used to store memories. To visualize
memory traces, we created a transgenic line that allows for the comparison between cells …

Targeting genetically encoded tools for neural circuit dissection to relevant cellular
populations is a major challenge in neurobiology. We developed an approach, targeted …