Methods Specific studies and articles were reviewed to illustrate what the test measures, to
evaluate its sensitivity to change, and to discuss its use in clinical practice. Results The …

Basic research advances in recent years have furthered our understanding of the natural
history of Alzheimer's disease (AD). It is now recognized that pathophysiological changes …

Importance Neurofibrillary tangles composed of aggregated tau protein are one of the
neuropathological hallmarks of Alzheimer disease (AD) and correlate with clinical disease …

The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

Objectives: To describe the frequency of co-occurring newly acquired cognitive impairment,
disability in activities of daily livings, and depression among survivors of a critical illness and …

Background: Postoperative delirium and postoperative cognitive dysfunction share risk
factors and may co-occur, but their relationship is not well-established. The primary goals of …

Background The risk of dementia is higher in women than men. The metabolic
consequences of estrogen decline during menopause accelerate neuropathology in …

Objectives: This guideline provides recommendations for the clinical management of
schizophrenia and related disorders for health professionals working in Australia and New …

Background Delirium during critical illness results from numerous insults, which might be
interconnected and yet individually contribute to long-term cognitive impairment. We sought …

Animal and computational models of Alzheimer's disease (AD) indicate that early amyloid-β
(Aβ) deposits drive neurons into a hyperactive regime, and that subsequent tau depositions …