RAF family protein kinases are a key node in the RAS/RAF/MAP kinase pathway, the
signaling cascade that controls cellular proliferation, differentiation, and survival in response …

Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

Abstract The 14-3-3 family of proteins mediates signal transduction by binding to
phosphoserine-containing proteins. Using phosphoserine-oriented peptide libraries to …

The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all
eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of …

The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …

The highly conserved and ubiquitously expressed 14-3-3 family of proteins bind to a variety
of proteins involved in signal transduction and cell cycle regulation. The nature and …

▪ Abstract Nitrate reductase (NR; EC 1.6. 6.1-3) catalyzes NAD (P) H reduction of nitrate to
nitrite. NR serves plants, algae, and fungi as a central point for integration of metabolism by …

This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the
differences between potentially cancer-relevant isoforms on the genomic, protein and …

Pyrin, encoded by the MEFV gene, is best known for its gain-of-function mutations causing
familial Mediterranean fever (FMF), an autoinflammatory disease. Pyrin forms a caspase-1 …

14-3-3 proteins were the first signaling molecules to be identified as discrete phosphoserine/
threonine binding modules. This family of proteins, which includes seven isotypes in human …