With the incidence and impact of atherosclerotic cardiovascular disease and its clinical
manifestations still rising, therapeutic options that target the causal mechanisms of this …

CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8),
are expressed in a variety of cells including, leukocytes, fibroblasts, endothelial cells, and …

Inflammation plays a crucial role in the onset and development of atherosclerosis.
Periodontitis is a common chronic disease linked to other chronic inflammatory diseases …

Atherosclerosis is the leading cause of death worldwide and leukocyte recruitment is a key
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …

Randomised controlled trials often use surrogate endpoints to substitute for a target outcome
(an outcome of direct interest and relevance to trial participants, clinicians, and other …

Chemokines orchestrate leukocyte recruitment in atherosclerosis and their blockade is a
promising anti-atherosclerotic strategy, but few chemokine-based approaches have …

Rationale Increased IL-8 levels and neutrophil accumulation in the airways are common
features found in patients affected by pulmonary diseases such as Asthma, Idiopathic …

Coronary artery disease (CAD) is the leading cause of death worldwide. It is a result of the
buildup of atherosclerosis within the coronary arteries. The role of the immune system in …

Chemokines and their receptors represent a potential target for immunotherapy in chronic
inflammation. They comprise a large family of cytokines with chemotactic activity, and their …

Recent findings have modified our understanding of the roles of chemokine receptor CXCR2
and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific …