Caffeine is the most widely consumed behaviorally active substance in the world. Almost all
caffeine comes from dietary sources (beverages and food), most of it from coffee and tea …

Of the many slow-acting neurotransmitters utilized by concentration (50 μM) in virtually all
medium spiny the mammalian central nervous system, dopamine has neurons (Ouimet et …

Caffeine, the most widely used psychoactive compound, is an adenosine receptor
antagonist. It promotes wakefulness by blocking adenosine A2A receptors (A2ARs) in the …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

The adenosine A 2A receptor has emerged as an attractive non-dopaminergic target in the
pursuit of improved therapy for Parkinson's disease (PD), based in part on its unique CNS …

Considerable evidence indicates that adenosine may be an endogenous somnogen, yet the
mechanism through which it promotes sleep is unknown. Adenosine may act via A1 …

Caffeine is the most widely consumed, behaviorally active substance in the world. Average
caffeine consumption in humans can range in different cultures and nations from 80 to 400 …

DARPP-32 is a dual-function protein kinase/phosphatase inhibitor that is involved in striatal
signaling. The phosphorylation of DARPP-32 at threonine 34 is essential for mediating the …

In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A2A
receptor has emerged as an attractive nondopaminergic target. Based on the compelling …

Despite the importance and frequency of levodopa-induced dyskinesias, little is known
about their causal mechanisms. In this study, electrophysiological single-unit recordings of …