RNA viruses include many important human and animal pathogens, such as the influenza
viruses, respiratory syncytial virus, Ebola virus, measles virus and rabies virus. The …

The azaindole (AI) framework continues to play a significant role in the design of new
antiviral agents. Modulating the position and isosteric replacement of the nitrogen atom of AI …

Annual and sporadic influenza outbreaks pose a great threat to human health and the
economy worldwide. Moreover, the frequent mutation of influenza viruses caused by antigen …

Influenza A viruses cause seasonal epidemics and global pandemics, representing a
considerable burden to healthcare systems. Central to the replication cycle of influenza …

A novel Michael/alkylation cascade reaction of N-unprotected 3-bromooxindoles with α, β-
unsaturated acyl phosphonates using DABCO as a robust catalyst followed by the …

The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been
identified as a promising target for the treatment of influenza. To expand the chemical space …

We designed and synthesized 18 substituted indole derivatives containing a triazole scaffold
as novel anti-influenza A virus candidates using a bio-isosteric and scaffold-hopping …

An efficient N-heterocyclic carbene (NHC)-catalyzed enantioselective [3+ 3] annulation of 2-
bromoenals with 2-amino-1H-indoles has been developed. A series of functionalized 2-aryl …

Influenza is an acute respiratory infectious disease caused by influenza virus, leading to
huge morbidity and mortality in humans worldwide. Despite the availability of antivirals in the …

Nucleosides and their derivatives are a well-known and well-described class of compounds
with antiviral activity. Currently, in the era of the COVID-19 pandemic, scientists are also …