[HTML][HTML] Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases
JX Yang, JC Tseng, GY Yu, Y Luo, CYF Huang… - Pharmaceutics, 2022 - mdpi.com
Vaccines are powerful tools for controlling microbial infections and preventing epidemic
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …
[HTML][HTML] Toll-like receptor-targeted anti-tumor therapies: Advances and challenges
Y Yang, H Li, C Fotopoulou, P Cunnea… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are pattern recognition receptors, originally discovered to
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …
stimulate innate immune reactions against microbial infection. TLRs also play essential roles …
An aluminum hydroxide: CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice
E Nanishi, F Borriello, TR O'Meara… - Science translational …, 2021 - science.org
Global deployment of vaccines that can provide protection across several age groups is still
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …
urgently needed to end the COVID-19 pandemic, especially in low-and middle-income …
A novel therapeutic vaccine based on graphene oxide nanocomposite for tumor immunotherapy
L Zhang, L Xu, Y Wang, J Liu, G Tan, F Huang… - Chinese Chemical …, 2022 - Elsevier
With an intensive understanding of the mechanism of immune system, developing a
therapeutic tumor vaccine is one of the most perspective strategy of cancer immunotherapy …
therapeutic tumor vaccine is one of the most perspective strategy of cancer immunotherapy …
[HTML][HTML] Clinical applications of single-stranded oligonucleotides: current landscape of approved and in-development therapeutics
J Scharner, I Aznarez - Molecular Therapy, 2021 - cell.com
Single-stranded oligonucleotides have been explored as a therapeutic modality for more
than 20 years. Only during the last 5 years have single-stranded oligonucleotides become a …
than 20 years. Only during the last 5 years have single-stranded oligonucleotides become a …
Recent Developments in Nanoparticle‐Based Photo‐Immunotherapy for Cancer Treatment
Phototherapy is an emerging approach for cancer treatment that is effective at controlling the
growth of primary tumors. In the presence of light irradiation, photothermal and …
growth of primary tumors. In the presence of light irradiation, photothermal and …
The important role of non‐covalent drug‐protein interactions in drug hypersensitivity reactions
WJ Pichler - Allergy, 2022 - Wiley Online Library
Drug hypersensitivity reactions (DHR) are heterogeneous and unusual immune reactions
with rather unique clinical presentations. Accumulating evidence indicates that certain non …
with rather unique clinical presentations. Accumulating evidence indicates that certain non …
[HTML][HTML] Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 …
Massive production of efficacious SARS-CoV-2 vaccines is essential for controlling the
ongoing COVID-19 pandemic. We report here the preclinical development of yeast …
ongoing COVID-19 pandemic. We report here the preclinical development of yeast …
Anti-cocaine vaccine development: Where are we now and where are we going?
RJ Stephenson, I Toth - Journal of Medicinal Chemistry, 2023 - ACS Publications
Cocaine is one of the oldest and most widely used illicit drugs in the world and is
responsible for major worldwide medical and social problems. Drug addiction is a disease …
responsible for major worldwide medical and social problems. Drug addiction is a disease …
[HTML][HTML] Therapeutic liposomal vaccines for dendritic cell activation or tolerance
NA Nagy, AM De Haas, TBH Geijtenbeek… - Frontiers in …, 2021 - frontiersin.org
Dendritic cells (DCs) are paramount in initiating and guiding immunity towards a state of
activation or tolerance. This bidirectional capacity of DCs sets them at the center stage for …
activation or tolerance. This bidirectional capacity of DCs sets them at the center stage for …