Valproic acid (VPA), a branched short-chain fatty acid, is widely used as an antiepileptic
drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of …

Valproic acid (VPA) is an approved drug for managing epileptic seizures, bipolar disorders,
and migraine. VPA has been shown to elevate the level of gamma-aminobutyric acid …

Valproate is currently one of the major antiepileptic drugs with efficacy for the treatment of
both generalized and partial seizures in adults and children. Furthermore, the drug is …

In the past decade, nine new drugs have been licensed for the treatment of epilepsy. With
limited clinical experience of these agents, the mechanisms of action of antiepileptic drugs …

Valproic acid (VPA, 2-propylpentanoic acid) has been widely used as an antiepileptic drug
and for the therapy of bipolar disorders for several years. Its mechanism of action was …

Valproic acid (VPA) is a well-established anticonvulsant drug discovered serendipitously
and marketed for the treatment of epilepsy, migraine, bipolar disorder and neuropathic pain …

More than 50 million persons worldwide suffer from epilepsy, many of whom are refractory to
treatment with standard antiepileptic drugs (AEDs). Fortunately, new AEDs commercialized …

The management of seizures in the patient with epilepsy relies heavily on antiepileptic drug
(AED) therapy. Fortunately, for a large percentage of patients, AEDs provide excellent …

Valproic acid (VPA) is widely recognized for its use in the control of epilepsy and other
neurological disorders in the past 50 years. Recent evidence has shown the potential of …

Levetiracetam (ucb L059; Keppra™) is a novel antiepileptic drug. Its effects on action
potential generation and voltage-operated potassium currents were studied in acutely …