Raging the war against inflammation with natural products
Over the last few decade Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the drugs of
choice for treating numerous inflammatory diseases including rheumatoid arthritis. The …
choice for treating numerous inflammatory diseases including rheumatoid arthritis. The …
Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid
WS Powell, J Rokach - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2015 - Elsevier
Arachidonic acid can be oxygenated by a variety of different enzymes, including
lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a …
lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a …
Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology
H Harizi, JB Corcuff, N Gualde - Trends in molecular medicine, 2008 - cell.com
Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that
regulate a wide variety of physiological responses and pathological processes. They are …
regulate a wide variety of physiological responses and pathological processes. They are …
Molecular targets of phytochemicals for cancer prevention
KW Lee, AM Bode, Z Dong - Nature Reviews Cancer, 2011 - nature.com
Although successful for a limited number of tumour types, the efficacy of cancer therapies,
especially for late-stage disease, remains poor overall. Many have argued that this could be …
especially for late-stage disease, remains poor overall. Many have argued that this could be …
Anticancer potential of silymarin: from bench to bed side
Silymarin consists of a family of flavonoids (silybin, isosilybin, silychristin, silydianin and
taxifoline) commonly found in the dried fruit of the milk thistle plant Silybum marianum …
taxifoline) commonly found in the dried fruit of the milk thistle plant Silybum marianum …
The role of inflammation in colon cancer
NB Janakiram, CV Rao - Inflammation and cancer, 2014 - Springer
Colorectal cancer (CRC) is the one of the leading causes of cancer-related deaths in the
world. CRC is responsible for more than 600,000 deaths annually and incidence rates are …
world. CRC is responsible for more than 600,000 deaths annually and incidence rates are …
[6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase
Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic
activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts …
activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts …
Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1, 2, 3-triazole–coumarin hybrids
Abstract The 4-substituted 1, 2, 3-triazole core in designed coumarin hybrids (4–35) with
diverse physicochemical properties was introduced by eco-friendly copper (I)-catalyzed …
diverse physicochemical properties was introduced by eco-friendly copper (I)-catalyzed …
Therapeutic options for 5-lipoxygenase inhibitors
O Werz, D Steinhilber - Pharmacology & therapeutics, 2006 - Elsevier
5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …
The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR)
MA Peraza, AD Burdick, HE Marin… - Toxicological …, 2006 - academic.oup.com
Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription
factors that modulate target gene expression in response to endogenous and exogenous …
factors that modulate target gene expression in response to endogenous and exogenous …