Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …

Myocardial infarction (MI) is the main cause for the progression of the left ventricle towards
congestive heart failure. The optimal healing after MI requires timely induction and …

Aims Although macrophage phenotypes have been well studied in the myocardial infarction
(MI) setting, this study investigated temporal neutrophil polarization and activation …

Unresolved inflammation is a major contributor to the development of heart failure following
myocardial infarction (MI). Pro-resolving lipid mediators, such as resolvins (eg RvD1), are …

Background: Loss of brain-derived neurotrophic factor (BDNF)/TrkB (tropomyosin kinase
receptor B) signaling accounts for brain and cardiac disorders. In neurons, β-adrenergic …

After an ischemic injury, the heart undergoes a complex process of structural and functional
remodeling that involves several steps, including inflammatory and fibrotic responses. In this …

Over the past three decades, numerous studies have shown a strong connection between
matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left …

Inflammation promotes healing in myocardial infarction but, if unresolved, leads to heart
failure. To define the inflammatory and resolving responses, we quantified leukocyte …

Neurotrophins (NTs) were first identified as target-derived survival factors for neurons of the
central and peripheral nervous system (PNS). They are known to control neural cell fate …

There is a lack of understanding in the cardiac remodeling field regarding the use of
nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This …