Empirical fitness landscapes and the predictability of evolution
JAGM De Visser, J Krug - Nature Reviews Genetics, 2014 - nature.com
The genotype–fitness map (that is, the fitness landscape) is a key determinant of evolution,
yet it has mostly been used as a superficial metaphor because we know little about its …
yet it has mostly been used as a superficial metaphor because we know little about its …
Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
Adaptation in protein fitness landscapes is facilitated by indirect paths
The structure of fitness landscapes is critical for understanding adaptive protein evolution.
Previous empirical studies on fitness landscapes were confined to either the neighborhood …
Previous empirical studies on fitness landscapes were confined to either the neighborhood …
Evolution in the light of fitness landscape theory
By formalizing the relationship between genotype or phenotype and fitness, fitness
landscapes harbor information on molecular and evolutionary constraints. The shape of the …
landscapes harbor information on molecular and evolutionary constraints. The shape of the …
Should evolutionary geneticists worry about higher-order epistasis?
Natural selection drives evolving populations up the fitness landscape, the projection from
nucleotide sequence space to organismal reproductive success. While it has long been …
nucleotide sequence space to organismal reproductive success. While it has long been …
Quantitative analyses of empirical fitness landscapes
IG Szendro, MF Schenk, J Franke, J Krug… - Journal of Statistical …, 2013 - iopscience.iop.org
The concept of a fitness landscape is a powerful metaphor that offers insight into various
aspects of evolutionary processes and guidance for the study of evolution. Until recently …
aspects of evolutionary processes and guidance for the study of evolution. Until recently …
The causes of epistasis
JAGM De Visser, TF Cooper… - Proceedings of the …, 2011 - royalsocietypublishing.org
Since Bateson's discovery that genes can suppress the phenotypic effects of other genes,
gene interactions—called epistasis—have been the topic of a vast research effort. Systems …
gene interactions—called epistasis—have been the topic of a vast research effort. Systems …
The structure of genotype-phenotype maps makes fitness landscapes navigable
SF Greenbury, AA Louis, SE Ahnert - Nature Ecology & Evolution, 2022 - nature.com
Fitness landscapes are often described in terms of 'peaks' and 'valleys', indicating an
intuitive low-dimensional landscape of the kind encountered in everyday experience. The …
intuitive low-dimensional landscape of the kind encountered in everyday experience. The …
A rugged yet easily navigable fitness landscape
Fitness landscape theory predicts that rugged landscapes with multiple peaks impair
Darwinian evolution, but experimental evidence is limited. In this study, we used genome …
Darwinian evolution, but experimental evidence is limited. In this study, we used genome …
Mutation bias shapes the spectrum of adaptive substitutions
Evolutionary adaptation often occurs by the fixation of beneficial mutations. This mode of
adaptation can be characterized quantitatively by a spectrum of adaptive substitutions, ie, a …
adaptation can be characterized quantitatively by a spectrum of adaptive substitutions, ie, a …