One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

In recent years, significant progress has been made in understanding the geometric and
electronic structures of the active sites of non-heme iron enzymes and the contributions of …

Methanotrophic bacteria are capable of using methane as their sole source of carbon and
energy. The first step in methane metabolism, the oxidation of methane to methanol, is …

Ribonucleotide reductase (RNR) is the enzyme responsible for the conversion of
ribonucleotides to 2′-deoxyribonucleotides and thereby provides the precursors needed …

Ribonucleotide reductases (RNRs) catalyze all new production in nature of
deoxyribonucleotides for DNA synthesis by reducing the corresponding ribonucleotides. The …

De novo protein design provides an attractive approach for the construction of models to
probe the features required for function of complex metalloproteins. The metal-binding sites …

The oxidation of methane to methanol is performed at carboxylate-bridged dinuclear iron
centers in the soluble methane monooxygenase hydroxylase (MMOH). Previous structural …

The alternative oxidase is a ubiquinol oxidase found in plant mitochondria, as well as in the
mitochondria of some fungi and protists. It catalyzes a cyanide-resistant reduction of oxygen …

The four-component toluene/o-xylene monooxygenase (ToMO) from Pseudomonas stutzeri
OX1 is capable of oxidizing arenes, alkenes, and haloalkanes at a carboxylate-bridged …

The invention of a molecular device that permits the cleavage of water into molecular
oxygen and metabolically bound hydrogen by solar radiation is of paramount importance for …