Neuroinflammation in psychiatric disorders: PET imaging and promising new targets
Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics
E Kamma, W Lasisi, C Libner, HS Ng… - Journal of …, 2022 - Springer
There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …
Choroid plexus enlargement in inflammatory multiple sclerosis: 3.0-T MRI and translocator protein PET evaluation
VAG Ricigliano, E Morena, A Colombi, M Tonietto… - Radiology, 2021 - pubs.rsna.org
Background Choroid plexuses (CPs) have been suggested as a key gateway for
inflammation in experimental autoimmune encephalitis, but in vivo evidence of their …
inflammation in experimental autoimmune encephalitis, but in vivo evidence of their …
Neuroinflammation in schizophrenia: the role of nuclear factor kappa B
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …
subset of people with schizophrenia, with significant increases in inflammatory markers …
Cellular sources of TSPO expression in healthy and diseased brain
E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
[HTML][HTML] Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization
TR Guilarte, AN Rodichkin, JL McGlothan… - Pharmacology & …, 2022 - Elsevier
Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …
Neuronal activity increases translocator protein (TSPO) levels
The mitochondrial protein, translocator protein (TSPO), is a widely used biomarker of
neuroinflammation, but its non-selective cellular expression pattern implies roles beyond …
neuroinflammation, but its non-selective cellular expression pattern implies roles beyond …
Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia
Translocator protein (TSPO) expression is increased in activated glia, and has been used as
a marker of neuroinflammation in PET imaging. However, the extent to which TSPO …
a marker of neuroinflammation in PET imaging. However, the extent to which TSPO …
Chronic inflammation in multiple sclerosis—seeing what was always there
PM Matthews - Nature Reviews Neurology, 2019 - nature.com
Activation of innate immune cells and other compartmentalized inflammatory cells in the
brains and spinal cords of people with relapsing–remitting multiple sclerosis (MS) and …
brains and spinal cords of people with relapsing–remitting multiple sclerosis (MS) and …