Abstract Chimeric Antigen Receptor (CAR) T-cells represent a breakthrough in personalized
cancer therapy. In this strategy, synthetic receptors comprised of antigen recognition …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …

Drought episodes decrease plant growth and productivity, which in turn cause high
economic losses. Plants naturally sense and respond to water stress by activating specific …

To elucidate principles operating in native biological systems and to develop novel
biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within …

Breast cancer is a sporadic disease with genetic and epigenetic components. Genomic
instability in breast cancer leads to mutations, copy number variations, and genetic …

Scientific advances over the past several decades have accelerated the ability to engineer
existing organisms and to potentially create novel ones not found in nature. Synthetic …

The CRISPR–Cpf1 endonuclease has recently been demonstrated as a powerful tool to
manipulate targeted gene sequences. Here, we performed an extensive screening of split …

The daunting task of feeding an ever-growing population is an immense challenge for the
contemporary scientific community, especially in view of the rapidly changing climate …