Experimental models have often been at the origin of immunological paradigms such as the
M1/M2 dichotomy following macrophage polarization. However, this clear dichotomy in …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Macrophages have protective roles in immunity to pathogens, tissue development,
homeostasis and repair following damage. Maladaptive immunity and inflammation provoke …

Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …

Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We
conducted a first-in-human, phase 1 dose-escalation trial of autologous macrophage …

Immune regulation is fundamental to any immune response to ensure that it is appropriate
for the perceived threat to the host. Following cell and organ transplantation, it is essential to …

As an essential component of immunity, macrophages have key roles in mammalian host
defense, tissue homeostasis, and repair, as well as in disease pathogenesis and …

Cell therapy is a promising strategy for treating patients suffering from autoimmune or
inflammatory diseases or receiving a transplant. Based on our preclinical studies, we have …

Background Immune monitoring by flow cytometry is a fast and highly informative way of
studying the effects of novel therapeutics aimed at reducing transplant rejection or treating …

Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based
adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that …