The central cholinergic system includes the basal forebrain nuclei, mainly projecting to the
cortex, the mesopontine tegmental nuclei, mainly projecting to the thalamus and subcortical …

Sleep disorders are integral to Parkinson's disease (PD). Insomnia, an inability to maintain
stable sleep, affects most patients and is widely rated as one of the most debilitating facets of …

Background Parkinson's disease (PD) comorbid with rapid eye movement sleep behavior
disorder (RBD) may show more severe motor and nonmotor symptoms, suggesting a distinct …

Background The synthetic tetrahydrocannabinol analogue nabilone improved overall non‐
motor symptom (NMS) burden in Parkinson's disease (PD) patients in comparison to …

Rapid eye movement (REM) sleep behavior disorder (RBD) is associated with Parkinson's
disease (PD). In this study, a smartwatch-based sensor is utilized as a convenient tool to …

In Parkinson's disease (PD), it remains unclear whether sleep disorders including insomnia,
REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), restless legs …

Dysfunction of the glymphatic system, an intracranial clearance pathway that drains
misfolded proteins, has been implicated in the onset of Parkinson's disease (PD). Recently …

Introduction: The burden of non-motor symptoms (NMS) is a major determinant of health-
related quality of life in Parkinson's disease (PD), particularly at its late stage. Areas covered …

Abstract Purpose of Review Sleep disturbances are an important nonmotor feature of
Parkinson's disease (PD) that can cause polysomnographic (PSG) alterations. These …

Circadian rhythms are involved in the regulation of many aspects of the body, including cell
function, physical activity and disease. Circadian disturbance often predates the typical …