Ribosome biogenesis and translation control are essential cellular processes that are
governed at numerous levels. Several tumour suppressors and proto-oncogenes have been …

Tumor formation arises as a consequence of alterations in the control of cell proliferation
and disorders in the interactions between ceils and their surroundings that result in invasion …

Cancer is driven by mutation. Worldwide, tobacco smoking is the principal lifestyle exposure
that causes cancer, exerting carcinogenicity through> 60 chemicals that bind and mutate …

Meningiomas are common central nervous system tumours which present usually in the 4th
and 5th decades of life. Loss of constitutional heterozygosity on chromosome 22 in 60% of …

Human cervical carcinoma cell lines that were either positive or negative for human
papillomavirus (HPV) DNA sequences were analyzed for evidence of mutation of the p53 …

The retinoblastoma gene product (Rb) can interact eff iciently with two of three D-type G,
cyclins (D2 and D3) in vitro. Binding depended upon the minimal regions of Rb necessary …

The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function,
and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in …

Previously, we found that Rb can actively repress transcription of cell cycle genes by binding
and inactivating transcription factors at the promoter. Here, we demonstrate that Rb can also …

Alterations of various components of the cell cycle regulatory machinery that controls the
progression of cells from a quiescent to a growing state contribute to the development of …

Purpose: RB1 mutations and loss of retinoblastoma (Rb) expression represent consistent
but not entirely invariable hallmarks of small cell lung cancer (SCLC). The prevalence and …