Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
[PDF][PDF] YAP/TAZ at the roots of cancer
F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
Targeted Drug/Gene/Photodynamic Therapy via a Stimuli‐Responsive Dendritic‐Polymer‐Based Nanococktail for Treatment of EGFR‐TKI‐Resistant Non‐Small‐Cell …
J Huang, C Zhuang, J Chen, X Chen, X Li… - Advanced …, 2022 - Wiley Online Library
Yes‐associated protein (YAP) has been identified as a key driver for epidermal growth factor
receptor‐tyrosine kinase inhibitor (EGFR‐TKI) resistance. Inhibition of YAP expression could …
receptor‐tyrosine kinase inhibitor (EGFR‐TKI) resistance. Inhibition of YAP expression could …
Developmental pathways in the pathogenesis of lung fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …
Signaling cross talk between TGF-β/Smad and other signaling pathways
K Luo - Cold Spring Harbor perspectives in biology, 2017 - cshperspectives.cshlp.org
Cytokines of the transforming growth factor β (TGF-β) family, including TGF-βs, bone
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …
The emerging roles of YAP and TAZ in cancer
T Moroishi, CG Hansen, KL Guan - Nature Reviews Cancer, 2015 - nature.com
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ)
are the major downstream effectors of the Hippo pathway, which regulates tissue …
are the major downstream effectors of the Hippo pathway, which regulates tissue …
The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration
Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …
functionally conserved regulator of organ size and growth with crucial roles in cell …
[HTML][HTML] Many ways to resistance: How melanoma cells evade targeted therapies
I Kozar, C Margue, S Rothengatter, C Haan… - Biochimica et Biophysica …, 2019 - Elsevier
Melanoma is an aggressive malignancy originating from pigment-producing melanocytes.
The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies …
The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies …
[HTML][HTML] YAP/TAZ signaling as a molecular link between fibrosis and cancer
S Noguchi, A Saito, T Nagase - International journal of molecular sciences, 2018 - mdpi.com
Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …
[HTML][HTML] Regulation of TEAD transcription factors in cancer biology
HD Huh, DH Kim, HS Jeong, HW Park - Cells, 2019 - mdpi.com
Transcriptional enhanced associate domain (TEAD) transcription factors play important roles
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …