DNA mechanics and its biological impact
Almost all nucleoprotein interactions and DNA manipulation events involve mechanical
deformations of DNA. Extraordinary progresses in single-molecule, structural, and …
deformations of DNA. Extraordinary progresses in single-molecule, structural, and …
Adaptive homeostasis and the p53 isoform network
All living organisms have developed processes to sense and address environmental
changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour …
changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour …
[HTML][HTML] Structural basis for Cas9 off-target activity
The target DNA specificity of the CRISPR-associated genome editor nuclease Cas9 is
determined by complementarity to a 20-nucleotide segment in its guide RNA. However …
determined by complementarity to a 20-nucleotide segment in its guide RNA. However …
Geometric deep learning of protein–DNA binding specificity
Predicting protein–DNA binding specificity is a challenging yet essential task for
understanding gene regulation. Protein–DNA complexes usually exhibit binding to a …
understanding gene regulation. Protein–DNA complexes usually exhibit binding to a …
RNA conformational propensities determine cellular activity
Cellular processes are the product of interactions between biomolecules, which associate to
form biologically active complexes. These interactions are mediated by intermolecular …
form biologically active complexes. These interactions are mediated by intermolecular …
Deciphering the Role of the Ser‐Phosphorylation Pattern on the DNA‐Binding Activity of Max Transcription Factor Using Chemical Protein Synthesis
RV Nithun, YM Yao, X Lin, S Habiballah… - Angewandte Chemie …, 2023 - Wiley Online Library
The chemical synthesis of site‐specifically modified transcription factors (TFs) is a powerful
method to investigate how post‐translational modifications (PTMs) influence TF‐DNA …
method to investigate how post‐translational modifications (PTMs) influence TF‐DNA …
Predicting DNA structure using a deep learning method
Understanding the mechanisms of protein-DNA binding is critical in comprehending gene
regulation. Three-dimensional DNA structure, also described as DNA shape, plays a key …
regulation. Three-dimensional DNA structure, also described as DNA shape, plays a key …
High-throughput data and modeling reveal insights into the mechanisms of cooperative DNA-binding by transcription factor proteins
Cooperative DNA-binding by transcription factor (TF) proteins is critical for eukaryotic gene
regulation. In the human genome, many regulatory regions contain TF-binding sites in close …
regulation. In the human genome, many regulatory regions contain TF-binding sites in close …
Physicochemical models of protein–DNA binding with standard and modified base pairs
DNA-binding proteins play important roles in various cellular processes, but the
mechanisms by which proteins recognize genomic target sites remain incompletely …
mechanisms by which proteins recognize genomic target sites remain incompletely …
Single-particle combinatorial multiplexed liposome fusion mediated by DNA
Combinatorial high-throughput methodologies are central for both screening and discovery
in synthetic biochemistry and biomedical sciences. They are, however, often reliant on large …
in synthetic biochemistry and biomedical sciences. They are, however, often reliant on large …