HIF-1α exerts both detrimental and beneficial actions in atherosclerosis. While there is
evidence that HIF-1α could be pro-atherogenic within the atheromatous plaque …

Anemia is a common complication of chronic kidney disease; it is mainly treated with
erythropoiesis-stimulating agents (ESAs) and iron. Experimental studies extensively …

The hypoxia-inducing factor (HIF) is a central transcription factor in cellular oxygen sensing
and regulation. It is common that the inflammation always appears in many diseases, like …

Objectives Lysosomal acid lipase (LAL) is the key enzyme, which degrades neutral lipids at
an acidic pH in lysosomes. The role of LAL in various cellular processes has mostly been …

An immunosuppressive microenvironment promotes the occurrence and development of
tumors. Low apolipoprotein A1 (ApoA1) is closely related to tumor development, but the …

In a rapidly expanding body of literature, the major role of energy metabolism in determining
the response and polarization status of macrophages has been examined, and it is currently …

Alternative splicing (AS) allows the generation of multiple transcript variants from a single
gene and affects biological processes by generating protein diversity in organisms. In total …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to low
therapeutic response rates and poor prognoses. Majority of patients present with symptoms …

Obesity is a major public health concern because it increases the risk of several diseases,
including cancer. Crosstalk between obesity and cancer seems to be very complex, and the …

Maintenance of lipid homeostasis is essential for cell growth and survival and can be
dysregulated in disease [1]. Mammalian cells acquire lipids through both synthesis and …