Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Gastruloids are 3D structures generated from pluripotent stem cells recapitulating
fundamental principles of embryonic pattern formation. Using single-cell genomic analysis …

Region-specific gut spheroids are precursors for gastrointestinal and pulmonary organoids
that hold great promise for fundamental studies and translations. However, efficient …

The hindered diffusion model postulates that the movement of a signaling molecule through
an embryo is affected by tissue geometry and binding-mediated hindrance, but these effects …

How cells build embryos is still a major mystery. Many unresolved questions require the
study of the processes that pattern and shape the embryo in live specimens, in toto, across …

Micropatterning encompasses a set of methods aimed at precisely controlling the spatial
distribution of molecules onto the surface of materials. Biologists have borrowed the idea …

During embryonic development, the inductive molecules produced by local origins normally
arrive at their target tissues in a nondirectional, diffusion manner. The target organ precursor …

Pathological reprogramming of cardiomyocyte and fibroblast proteome landscapes drive the
initiation and progression of cardiac fibrosis. Although the secretome of dysfunctional …