Epidemiological surveys indicate that the incidence of inflammatory bowel disease (IBD) is
increasing rapidly with the continuous growth of the economy. A large number of studies …

The gastrointestinal tract is often considered as a key organ involved in the digestion of food
and providing nutrients to the body for proper maintenance. However, this system is …

Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …

The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial.
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …

Abstract The interleukin-23 [IL-23] cytokine, derived predominantly from macrophages and
dendritic cells in response to microbial stimulation, has emerged as a critical promoter of …

Mannose is a naturally occurring sugar widely consumed in the daily diet; however,
mechanistic insights into how mannose metabolism affects intestinal inflammation remain …

Background & Aims Excess and unresolved endoplasmic reticulum (ER) stress in intestinal
epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 …

The intestinal epithelium is a highly dynamic structure that rejuvenates in response to acute
stressors and can undergo alterations in cellular composition as animals age. The …

Tumor necrosis factor (TNF) drives chronic inflammation and cell death in the intestine, and
blocking TNF is a therapeutic approach in inflammatory bowel disease (IBD). Despite this …

The intestinal tract is a common site for various types of infections including viruses,
bacteria, and helminths, each requiring specific modes of immune defense. The intestinal …