Progress of the synthesis of condensed pyrazole derivatives (from 2010 to mid-2013)

M Li, BX Zhao - European Journal of Medicinal Chemistry, 2014 - Elsevier
Condensed pyrazole derivatives are important heterocyclic compounds due to their
excellent biological activities and have been widely applied in pharmaceutical and …

5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines

R Aggarwal, S Kumar - Beilstein Journal of Organic Chemistry, 2018 - beilstein-journals.org
The condensation of 5-aminopyrazole with various bielectrophilic moieties results in the
formation of pyrazoloazines, an interesting array of fused heterocyclic systems. The …

Synthesis and Biological Activity of Some New Pyrazolo [3, 4‐b] Pyrazines

TI El‐Emary - Journal of the Chinese Chemical Society, 2006 - Wiley Online Library
Abstract New derivatives of pyrazolo [3, 4‐b] pyrazine and related heterocycles were
prepared starting from 6‐amino‐3‐methyl‐1‐phenyl‐1H‐pyrazolo [3, 4‐b] pyrazine‐5 …

Synthesis and antileishmanial evaluation of 1-aryl-4-(4, 5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives

MS dos Santos, MLV Oliveira, AMR Bernardino… - Bioorganic & medicinal …, 2011 - Elsevier
A series of 1-aryl-4-(4, 5-dihydro-1H-imidazol-2-yl)-1H-pyrazoles (4a–g) and 5-amino-1-aryl-
4-(4, 5-dihydro-1H-imidazol-2-yl)-1H-pyrazoles (5a–g) were synthesized and evaluated in …

Structural characterization, thermal investigation and biological activity of metal complexes containing Schiff Base ligand (Z)‐3‐(1‐((4, 6‐dimethyl‐1H‐pyrazolo [3, 4‐b …

SM Emam, SA Abouel‐Enein… - Applied …, 2019 - Wiley Online Library
A new series of metal complexes containing Co (II), Pd (II), Fe (III) chloride and Cu (II) salts
(chloride, bromide, sulphate and perchlorate) have been prepared with Schiff base ligand …

Pyrazine derivatives—Versatile scaffold

N Tambat, SK Mulani, A Ahmad, SB Shaikh… - Russian Journal of …, 2022 - Springer
Pyrazines are important class of pharmacophores because of their versatility in
pharmacological activity. Pyrazines are among the most widely known heterocyclic …

A convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial …

RM Zaki, MA Abdul-Malik, SH Saber… - Medicinal Chemistry …, 2020 - Springer
A novel series of 5-amino-6-substituted-3-methyl-1-phenyl-1H-pyrazolo [3, 4-b] selenolo [3,
2-e] pyrazines (3a–e) was synthesized by the reaction of the chloro pyrazolo [3, 4-b] …

[HTML][HTML] Multi-component one-pot synthesis and antimicrobial activities of 3-methyl-1, 4-diphenyl-7-thioxo-4, 6, 8, 9-tetrahydro-pyrazolo [5, 4-b] pyrimidino [5, 4-e] …

TI El-Emary, SAA El-Mohsen - Molecules, 2012 - mdpi.com
The synthesis of 3-methyl-1, 4-diphenyl-7-thioxo-4, 6, 8, 9-tetrahydropyrazolo [5, 4-b]
pyrimidino [5, 4-e] pyridine-5-one (6) was achieved by two different one-pot multi-component …

Synthesis and anticonvulsant activity of some new pyrazolo [3, 4-b] pyrazines and related heterocycles

AR Farghaly, S Esmail, A Abdel-Zaher… - Bioorganic & Medicinal …, 2014 - Elsevier
A series of new pyrazolo [3, 4-b] pyrazines containing, 1, 2, 4-oxadiazolyl, thiadiazolyl,
imidazothiadiazolyl, thiazolidinonyl, substituents and other different substituents, was …

Synthesis of Newly Substituted Pyrazoles and Substituted Pyrazolo[3,4‐b]Pyridines Based on 5‐Amino‐3‐Methyl‐1‐Phenylpyrazole

TI El‐Emary - Journal of the Chinese Chemical Society, 2007 - Wiley Online Library
The reaction of the aminopyrazole 1 with benzenesulfonyl chloride, arenediazonium salt,
chloroacetyl chloride, ethoxy methyleneamlononitrile and with ethyl 2‐cyano‐3 …