Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production
versus consumption, may be involved in the pathogenesis of different diseases. The only …

Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a
multifunctional compound, which catalyzes several essential reactions for the protection of …

Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …

Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

Neuroprotection aims to prevent salvageable neurons from dying. Despite showing efficacy
in experimental stroke studies, the concept of neuroprotection has failed in clinical trials …

Thioredoxin system is a ubiquitous disulfide reductase system evolutionarily conserved
through all living organisms. It contains thioredoxin (Trx), thioredoxin reductase (TrxR) and …

Oxidative stress is a key player in both chronic and acute brain disease due to the higher
metabolic demand of the brain. Among the producers of free radicals, NADPH-oxidase …

In vitro and in vivo experimental models clearly demonstrate the efficacy of Se compounds
as anticancer agents, contingent upon chemical structures and concentrations of test …

Ischemic stroke accounts for nearly 80% of stroke cases. Recanalization with thrombolysis is
a currently crucial therapeutic strategy for re-building blood supply, but the thrombolytic …

Selenium (34Se), an antioxidant trace element, is an important regulator of brain function.
These beneficial properties that Se possesses are attributed to its ability to be incorporated …