Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Simple Summary Many microorganisms develop resistance to drugs through different
mechanisms, and this process is called antimicrobial resistance. It is highly essential to …

The microorganisms that have developed resistance to available therapeutic agents are
threatening the globe and multidrug resistance among the bacterial pathogens is becoming …

Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

Epithelial-to-mesenchymal transition (EMT) is a process that involves the transformation of
polarized epithelial cells to attain a mesenchymal phenotype that presents an elevated …

Cancer stands in the frontline among leading killers worldwide and the annual mortality rate
is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of …

In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an
intriguing subject of study for their complex structural characteristics, their finely regulated …

Heparanase (HPSE) is an endoglycosidase that catalyses the cutting of the side chains of
heparan-sulphate proteoglycans (HS), thus determining the remodelling of the extracellular …

Complex carbohydrates (glycans) are major players in all organisms due to their structural,
energy, and communication roles. This last essential role involves interacting and/or …

Heparanase has been viewed as a promising anti-cancer drug target for almost two
decades, but no anti-heparanase therapy has yet reached the clinic. This endoglycosidase …