Plant antimicrobial peptides (AMPs) have evolved differently from AMPs from other life
forms. They are generally rich in cysteine residues which form multiple disulfides. In turn, the …

Covering: 1988 to 2012 This review presents recommended nomenclature for the
biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) …

This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Covering: up to May 2012 Lasso peptides are a class of ribosomally-synthesized and
posttranslationally-modified natural products with diverse bioactivities. This review describes …

Selective pressure imposed by millions of years of relentless biological attack has led to the
development of an extraordinary array of defense strategies in plants. Among these …

There has been a spurt in the spread of microbial resistance to antibiotics due to
indiscriminate use of antimicrobial agents in human medicine, agriculture, and animal …

CyBase was originally developed as a database for backbone-cyclized proteins, providing
search and display capabilities for sequence, structure and function data. Cyclic proteins are …

Cyclotides are disulfide-rich miniproteins with the unique structural features of a circular
backbone and knotted arrangement of three conserved disulfide bonds. Cyclotides have …

Conotoxins (CTXs), with their exquisite specificity and potency, have recently created much
excitement as drug leads. However, like most peptides, their beneficial activities may …

Even before the perception or interaction with pathogens, plants rely on constitutively
guardian molecules, often specific to tissue or stage, with further expression after contact …