Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

Mitotic kinesin-5 bipolar motor proteins perform essential functions in mitotic spindle
dynamics by crosslinking and sliding antiparallel microtubules (MTs) apart within the mitotic …

Several kinesin-5 motors (kinesin-5s) exhibit bidirectional motility. The mechanism of such
motility remains unknown. Bidirectional kinesin-5s share a long N-terminal nonmotor …

Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are
homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament …

Kinesin-5 motor proteins play essential roles during mitosis in most organisms. Their
tetrameric structure and plus-end-directed motility allow them to bind to and move along …

Mitosis mediates the accurate separation of daughter cells, and abnormalities are closely
related to cancer progression. KIF11, a member of the kinesin family, plays a vital role in the …

Kinesin-5 crosslinks and slides apart microtubules to assemble, elongate, and maintain the
mitotic spindle. Kinesin-5 is a tetramer, where two N-terminal motor domains are positioned …

Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during
mitotic cell division. Their specialized structural characteristics enable these motors to …

Kinesin motors play central roles in bipolar spindle assembly. In many eukaryotes, spindle
pole separation is driven by kinesin-5, which generates outward force. This outward force is …

Most kinesin motors move in only one direction along microtubules. Members of the kinesin-
5 subfamily were initially described as unidirectional plus-end-directed motors and shown to …