The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities
X He, Y Li, B Deng, A Lin, G Zhang, M Ma… - Cell …, 2022 - Wiley Online Library
Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …
the injured segment of the spinal cord, which significantly impacts the quality of life in …
Blood–spinal cord barrier in spinal cord injury: a review
LY Jin, J Li, KF Wang, WW Xia, ZQ Zhu… - Journal of …, 2021 - liebertpub.com
The blood–spinal cord barrier (BSCB), a physical barrier between the blood and spinal cord
parenchyma, prevents the toxins, blood cells, and pathogens from entering the spinal cord …
parenchyma, prevents the toxins, blood cells, and pathogens from entering the spinal cord …
[HTML][HTML] Betulinic acid inhibits pyroptosis in spinal cord injury by augmenting autophagy via the AMPK-mTOR-TFEB signaling pathway
C Wu, H Chen, R Zhuang, H Zhang… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) results in a wide range of disabilities. Its complex pathophysiological
process limits the effectiveness of many clinical treatments. Betulinic acid (BA) has been …
process limits the effectiveness of many clinical treatments. Betulinic acid (BA) has been …
Advances in Bone tissue engineering: A fundamental review
BM Manzini, LMR Machado, PY Noritomi… - Journal of …, 2021 - Springer
Bone is a dynamic tissue that can always rebuild itself by modeling and remodeling to
maintain functionality. This tissue is responsible for several vital functions in the body, such …
maintain functionality. This tissue is responsible for several vital functions in the body, such …
[HTML][HTML] TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress
K Zhou, Z Zheng, Y Li, W Han, J Zhang, Y Mao… - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Background and Aim: Increasing evidence suggests that spinal cord injury (SCI)-
induced defects in autophagic flux may contribute to an impaired ability for neurological …
induced defects in autophagic flux may contribute to an impaired ability for neurological …
Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals
Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …
motor function. Understanding the precise dysregulated signaling pathways, especially …
[HTML][HTML] The role of PI3K/Akt signalling pathway in spinal cord injury
CL Xiao, WC Yin, YC Zhong, JQ Luo, LL Liu… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a severely disabling central nervous system injury with complex
pathological mechanisms that leads to sensory and motor dysfunction. The current treatment …
pathological mechanisms that leads to sensory and motor dysfunction. The current treatment …
Osteogenesis and bone remodeling: A focus on growth factors and bioactive peptides
S Toosi, J Behravan - Biofactors, 2020 - Wiley Online Library
Bone is one of the most frequently transplanted tissues. The bone structure and its
physiological function and stem cells biology were known to be closely related to each other …
physiological function and stem cells biology were known to be closely related to each other …
The Anti-Scar Effects of Basic Fibroblast Growth Factor on the Wound Repair In Vitro and In Vivo
HX Shi, C Lin, BB Lin, ZG Wang, HY Zhang, FZ Wu… - PloS one, 2013 - journals.plos.org
Hypertrophic scars (HTS) and keloids are challenging problems. Their pathogenesis results
from an overproduction of fibroblasts and excessive deposition of collagen. Studies suggest …
from an overproduction of fibroblasts and excessive deposition of collagen. Studies suggest …
Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury
AM Siddiqui, M Khazaei, MG Fehlings - Progress in brain research, 2015 - Elsevier
One of the big challenges in neuroscience that remains to be understood is why the central
nervous system is not able to regenerate to the extent that the peripheral nervous system …
nervous system is not able to regenerate to the extent that the peripheral nervous system …