Plasmodium falciparum Malaria Vaccines and Vaccine Adjuvants

SR Bonam, L Rénia, G Tadepalli, J Bayry, HMS Kumar - Vaccines, 2021 - mdpi.com
Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …

[HTML][HTML] The role of different components of the immune system against Plasmodium falciparum malaria: Possible contribution towards malaria vaccine development

WL Mandala, V Harawa, F Dzinjalamala… - Molecular and …, 2021 - Elsevier
Plasmodium falciparum malaria still remains a major global public health challenge with
over 220 million new cases and well over 400,000 deaths annually. Most of the deaths occur …

Tumour necrosis factor-α as a prognostic biomarker of severe malaria: a systematic review and meta-analysis

A Mahittikorn, W Mala, M Srisuphanunt… - Journal of Travel …, 2022 - academic.oup.com
Background Tumour necrosis factor-alpha (TNF-α) levels are reportedly altered during
malaria. In this systematic review and meta-analysis, we aimed to collect and compare data …

Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infection

R Furtado, M Paul, J Zhang, J Sung, P Karell… - Nature …, 2023 - nature.com
Clinical immunity against Plasmodium falciparum infection develops in residents of malaria
endemic regions, manifesting in reduced clinical symptoms during infection and in …

Immune effector mechanisms in malaria: An update focusing on human immunity

AM Moormann, CE Nixon, CS Forconi - Parasite immunology, 2019 - Wiley Online Library
The past decade has witnessed dramatic decreases in malaria‐associated mortality and
morbidity around the world. This progress has largely been due to intensified malaria control …

Serum proteomic profile of wild stump-tailed macaques (Macaca arctoides) infected with malaria parasites in Thailand

P Ruengket, S Roytrakul, D Tongthainan, K Taruyanon… - Plos one, 2023 - journals.plos.org
The number of patients infected with simian malaria is gradually increasing in many
countries of Southeast Asia and South America. The most important risk factor for a zoonotic …

Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis

KU Kotepui, P Kwankaew, FR Masangkay… - Tropical Medicine and …, 2022 - mdpi.com
Transforming growth factor-β (TGF-β) is important in the pathophysiology of malaria, but its
role in acute and severe malaria is largely unknown. As a result, this study used a meta …

Loss of humoral and cellular immunity to invasive nontyphoidal Salmonella during current or convalescent Plasmodium falciparum infection in Malawian children

TS Nyirenda, JT Nyirenda, DL Tembo… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Invasive nontyphoidal Salmonella (iNTS) infections are commonly associated with
Plasmodium falciparum infections, but the immunologic basis for this linkage is poorly …

Model of severe malaria in young mice suggests unique response of CD4 T cells

MR Smith, K Gbedande, CM Johnson… - Parasite …, 2022 - Wiley Online Library
Severe malaria occurs most in young children but is poorly understood due to the absence
of a developmentally‐equivalent rodent model to study the pathogenesis of the disease …

Parasitic Infection and Autoimmunity

E Ling, M Abu-Shakra - Infection and Autoimmunity, 2024 - Elsevier
Throughout the evolution humans co-exist with plethora of parasites. Host-parasite
interactions are extraordinary complex and may result in elimination of the parasite …