Sickle cell disease is a very variable condition, with outcomes ranging from death in
childhood to living relatively symptom free into the 8 th decade. Much of this variability is …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Sickle cell disease (SCD) is characterized by variable clinical outcomes, with some patients
suffering life-threatening complications during childhood, and others living relatively …

Silent cerebral infarcts (SCI) are common in patients with sickle cell disease (SCD). Up to
35% of children with HbSS will have an SCI by the age of 15 years, and this prevalence has …

Introduction. Rising studies indicate that the apolipoprotein E (APOE) gene is related to the
susceptibility of ischemic stroke (IS). However, certain consensus is limited by the lack of a …

The long noncoding RNA (lncRNA) GAS5 has been shown to affect disease development in
stroke. This study aimed to elucidate the regulatory mechanism of the lncRNA GAS5 on …

Ischaemic stroke is a common complication of sickle cell disease (SCD) and without
intervention can affect 11% of children with SCD before the age of 20. Within the Trans …

Sickle cell anemia (SCA) is the most common cause of stroke in children. As it is a rare
disease, studies investigating the association with complications like stroke in SCD have …

Background: Sickle cell disease (SCD) is the commonest cause of stroke in children. As it is
a rare disease, studies investigating the association with complications like stroke in SCD …

Introduction. Rising studies indicate that the apolipoprotein E (APOE) gene is related to the
susceptibility of ischemic stroke (IS). However, certain consensus is limited by the lack of a …