The capsule of Cryptococcus neoformans

A Casadevall, C Coelho, RJB Cordero, Q Dragotakes… - Virulence, 2019 - Taylor & Francis
The capsule of Cryptococcus neoformans is its dominant virulence factor and plays a key
role in the biology of this fungus. In this essay, we focus on the capsule as a cellular …

Unraveling synthesis of the cryptococcal cell wall and capsule

ZA Wang, LX Li, TL Doering - Glycobiology, 2018 - academic.oup.com
Fungal pathogens cause devastating infections in millions of individuals each year,
representing a huge but underappreciated burden on human health. One of these, the …

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

B Hommel, L Mukaremera, RJB Cordero… - PLoS …, 2018 - journals.plos.org
The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell
size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> …

The tools for virulence of Cryptococcus neoformans

C Coelho, AL Bocca, A Casadevall - Advances in applied microbiology, 2014 - Elsevier
Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …

Elucidating the Immunological Function of the Cryptococcus Neoformans Capsule

A Vecchiarelli, E Pericolini, E Gabrielli… - Future …, 2013 - Taylor & Francis
The encapsulated fungal pathogen Cryptococcus neoformans represents a significant agent
of life-threatening infections in immunocompromised subjects. A unique characteristic of …

[HTML][HTML] The mechanical properties of microbial surfaces and biofilms

GRS Araújo, NB Viana, F Gómez, B Pontes, S Frases - The Cell Surface, 2019 - Elsevier
Microbes can modify their surface structure as an adaptive mechanism for survival and
dissemination in the environment or inside the host. Altering their ability to respond to …

Cryptococcus: History, Epidemiology and Immune Evasion

I Diniz-Lima, LM Fonseca, EB Silva-Junior… - Applied Sciences, 2022 - mdpi.com
Cryptococcosis is a disease caused by the pathogenic fungi Cryptococcus neoformans and
Cryptococcus gattii, both environmental fungi that cause severe pneumonia and may even …

Variation in cell surface hydrophobicity among Cryptococcus neoformans strains influences interactions with amoebas

R Vij, C Danchik, C Crawford, Q Dragotakes… - MSphere, 2020 - Am Soc Microbiol
Cryptococcus neoformans and Cryptococcus gattii are pathogenic fungi that cause
significant morbidity and mortality. Cell surface hydrophobicity (CSH) is a biophysical …

Cryptococcus neoformans: Tripping on Acid in the Phagolysosome

CM DeLeon-Rodriguez, A Casadevall - Frontiers in microbiology, 2016 - frontiersin.org
Cryptococcus neoformans (Cn) is a basidiomycetous pathogenic yeast that is a frequent
cause of meningoencephalitis in immunocompromised individuals. Cn is a facultative …

Fluconazole Alters the Polysaccharide Capsule of Cryptococcus gattii and Leads to Distinct Behaviors in Murine Cryptococcosis

JRA Santos, RA Holanda, S Frases, M Bravim… - PLoS …, 2014 - journals.plos.org
Cryptococcus gattii is an emergent human pathogen. Fluconazole is commonly used for
treatment of cryptococcosis, but the emergence of less susceptible strains to this azole is a …