Imbalanced copper homeostasis and perturbation of membrane trafficking are two common
symptoms that have been associated with the pathogenesis of neurodegenerative and …

One of the hallmarks of Parkinson's disease (PD) is the progressive loss of dopaminergic
neurons and associated dopamine depletion. Several mechanisms, previously considered …

The pentameric WASH complex facilitates endosomal protein sorting by activating Arp2/3,
which in turn leads to the formation of F‐actin patches specifically on the endosomal surface …

Background Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene cause late-
onset, autosomal dominant Parkinson's disease (PD), with a single missense mutation …

Endosomal trafficking ensures the proper distribution of lipids and proteins to various
cellular compartments, facilitating intracellular communication, nutrient transport, waste …

Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo
sorting from endosomal compartments. In concert with its accessory proteins, the retromer …

Alzheimer's disease and Parkinson's disease represent the most common forms of cognitive
impairment. Multiple sclerosis is a chronic inflammatory disease of the central nervous …

The identification of multiple genes linked to Parkinson's disease (PD) invites the question
as to how they may co-operate. We have generated isogenic cell lines that inducibly express …

The efficient and prolonged neurotransmission is reliant on the coordinated action of
numerous synaptic proteins in the presynaptic compartment that remodels synaptic vesicles …

Membrane trafficking is all about time. Automation in such a biological process is crucial to
ensure management and delivery of cellular cargoes with spatiotemporal precision. Shared …