Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system
Imbalanced copper homeostasis and perturbation of membrane trafficking are two common
symptoms that have been associated with the pathogenesis of neurodegenerative and …
symptoms that have been associated with the pathogenesis of neurodegenerative and …
Selective dopaminergic vulnerability in Parkinson's disease: new insights into the role of DAT
MM Harraz - Frontiers in Neuroscience, 2023 - frontiersin.org
One of the hallmarks of Parkinson's disease (PD) is the progressive loss of dopaminergic
neurons and associated dopamine depletion. Several mechanisms, previously considered …
neurons and associated dopamine depletion. Several mechanisms, previously considered …
SWIP mediates retromer‐independent membrane recruitment of the WASH complex
V Dostál, T Humhalová, P Beránková, O Pácalt… - Traffic, 2023 - Wiley Online Library
The pentameric WASH complex facilitates endosomal protein sorting by activating Arp2/3,
which in turn leads to the formation of F‐actin patches specifically on the endosomal surface …
which in turn leads to the formation of F‐actin patches specifically on the endosomal surface …
VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease
X Chen, E Tsika, N Levine, DJ Moore - Molecular Neurodegeneration, 2023 - Springer
Background Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene cause late-
onset, autosomal dominant Parkinson's disease (PD), with a single missense mutation …
onset, autosomal dominant Parkinson's disease (PD), with a single missense mutation …
Retromer‐mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21
M Romano‐Moreno, EN Astorga‐Simón… - Protein …, 2024 - Wiley Online Library
Endosomal trafficking ensures the proper distribution of lipids and proteins to various
cellular compartments, facilitating intracellular communication, nutrient transport, waste …
cellular compartments, facilitating intracellular communication, nutrient transport, waste …
Beware of misdelivery: multifaceted role of retromer transport in neurodegenerative diseases
S Yoshida, T Hasegawa - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo
sorting from endosomal compartments. In concert with its accessory proteins, the retromer …
sorting from endosomal compartments. In concert with its accessory proteins, the retromer …
Herpesviridae, Neurodegenerative Disorders and Autoimmune Diseases: What Is the Relationship between Them?
MA De Francesco - Viruses, 2024 - mdpi.com
Alzheimer's disease and Parkinson's disease represent the most common forms of cognitive
impairment. Multiple sclerosis is a chronic inflammatory disease of the central nervous …
impairment. Multiple sclerosis is a chronic inflammatory disease of the central nervous …
The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress
KR McCarron, H Elcocks, H Mortiboys… - Biochemical …, 2024 - portlandpress.com
The identification of multiple genes linked to Parkinson's disease (PD) invites the question
as to how they may co-operate. We have generated isogenic cell lines that inducibly express …
as to how they may co-operate. We have generated isogenic cell lines that inducibly express …
Neurons Specialize in Presynaptic Autophagy: A Perspective to Ameliorate Neurodegeneration
AK Mishra, MK Tripathi, D Kumar, SP Gupta - Molecular Neurobiology, 2024 - Springer
The efficient and prolonged neurotransmission is reliant on the coordinated action of
numerous synaptic proteins in the presynaptic compartment that remodels synaptic vesicles …
numerous synaptic proteins in the presynaptic compartment that remodels synaptic vesicles …
Deliver on time or pay the fine: scheduling in membrane trafficking
G Placidi, CC Campa - International Journal of Molecular Sciences, 2021 - mdpi.com
Membrane trafficking is all about time. Automation in such a biological process is crucial to
ensure management and delivery of cellular cargoes with spatiotemporal precision. Shared …
ensure management and delivery of cellular cargoes with spatiotemporal precision. Shared …