Epigenetics and lifestyle

JA Alegría-Torres, A Baccarelli, V Bollati - Epigenomics, 2011 - Taylor & Francis
The concept of 'lifestyle 'includes different factors such as nutrition, behavior, stress, physical
activity, working habits, smoking and alcohol consumption. Increasing evidence shows that …

Multiple sclerosis: risk factors, prodromes, and potential causal pathways

SV Ramagopalan, R Dobson, UC Meier… - The Lancet …, 2010 - thelancet.com
Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of
MS is not yet known, although epidemiological data indicate that both genetic and …

Epigenetic transgenerational actions of environmental factors in disease etiology

MK Skinner, M Manikkam… - Trends in Endocrinology & …, 2010 - cell.com
The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

RG Urdinguio, JV Sanchez-Mut, M Esteller - The Lancet Neurology, 2009 - thelancet.com
Epigenetic mechanisms such as DNA methylation and modifications to histone proteins
regulate high-order DNA structure and gene expression. Aberrant epigenetic mechanisms …

Environmental factors and their timing in adult-onset multiple sclerosis

AE Handel, G Giovannoni, GC Ebers… - Nature Reviews …, 2010 - nature.com
Multiple sclerosis (MS) is a common, complex neurological disease. Epidemiological data
implicate both genetic and environmental factors in the etiology of MS, with various factors …

Epigenetics: molecular mechanisms and implications for disease

AE Handel, GC Ebers, SV Ramagopalan - Trends in molecular medicine, 2010 - cell.com
Epigenetics is rising to prominence in biology as a mechanism by which environmental
factors have intermediate-term effects on gene expression without changing the underlying …

Epidemiology of multiple sclerosis

SV Ramagopalan, AD Sadovnick - Neurologic clinics, 2011 - neurologic.theclinics.com
Multiple sclerosis (MS) is the most common disease of the central nervous system that
causes permanent disability in young adults. 1 Based on strong circumstantial evidence, MS …

The increasing incidence and prevalence of female multiple sclerosis—a critical analysis of potential environmental factors

J Sellner, J Kraus, A Awad, R Milo, B Hemmer… - Autoimmunity …, 2011 - Elsevier
Multiple sclerosis (MS) is the most common acquired inflammatory demyelinating disorder of
the central nervous system (CNS). Not unlike many inflammatory diseases with a presumed …

Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis?

C Pierrot-Deseilligny, JC Souberbielle - Brain, 2010 - academic.oup.com
The role of hypovitaminosis D as a possible risk factor for multiple sclerosis is reviewed.
First, it is emphasized that hypovitaminosis D could be only one of the risk factors for multiple …

The epigenetics of autoimmunity

F Meda, M Folci, A Baccarelli, C Selmi - Cellular & molecular …, 2011 - nature.com
The etiology of autoimmune diseases remains largely unknown. Concordance rates in
monozygotic twins are lower than 50% while genome-wide association studies propose …